Over the past two decades, several methods have been developed [ 4- 13], which are based on different mutation (substitution) models with subtle yet significant differences [ 14- 16].
Since behavioural phenotypes of Rett models based on different Mecp2 mutations did not overlap [30], an assessment of each individual model is necessary.
Otherwise, the multi-allele markers were based on different point mutation positions within the locus that had more than two restriction sites.
Author's response: Probably, there are some theories of punctuational evolution based on different rate of mutations or different stringency of reparation processes during evolutionary stasis and during phase of accelerated evolution.
In order to compensate at least partially for the possibility of repeated mutation at the same site, a number of different distances are in use, based on different models of mutation.
They may all be placed in clade B/genotype J/clade 2 based on different SNP profiles [ 5– 9], but mutations also could be detected.
Frequencies of EMS-induced mutations identified during different TILLING experiments have been based on different samples sizes in different species.
Theoretically, phylogenetic reconstructions based on different housekeeping genes must result in concordant trees in a clonal population in which accumulation of mutations is solely responsible for genetic diversification.
Coalescence-based dating was carried out for the four high-D SNPs based on two different mutation rates (see Methods).
Fearon and Vogelstein (1990) first proposed a temporal ordering of mutations based on the mutations in colorectal tumors from different stages.
