Sentence examples for based on genetic mutations from inspiring English sources
Such intrinsic mechanisms also facilitate the development of resistance through acquired mechanisms that are based on genetic mutations or drug resistance genes.
Altered brain excitability has been supposed, based on genetic mutations and/or polymorphisms of chromosomes, yet to be determined, which regulate the metabolism of neuronal mitochondrial energy, neurotransmitters and ion canals of the CNS [1].
The distinct pattern of mutations and specific location of this unique intraocular tumor have paved the way for two types of models- those based on genetic mutations, and xenograft models.
Selection of patients based on genetic mutations will enrich for a population that could benefit and respond from sorafenib or other Raf or Ras inhibitors.
If areas of tumour with a high α/β could be targeted based on genetic mutations that impair DNA repair capability, and this capability manipulated to decrease the α/β ratio, the tumour may respond more effectively to hypofractionated schedules.
Longer follow-up of this cohort is planned and outcome data based on age and based on genetic risk category and genetic mutation status will be available in a further 12 months time.
Genome evolution is based on genetic variability generated by mutation, recombination, and the acquisition of new genes.
The model obtained may provide structural insights into this enzyme and can be useful for the design of new caseous lymphadenitis vaccines based on genetic attenuation from key point mutation.
The major bottle-neck of the phenotype-driven approach used to be the identification of the causative mutation based on genetic mapping followed by sequencing of candidate genes.
Methods based on genetic sequencing to monitor drug-resistance mutations in human immunodeficiency virus type 1 (HIV-1) require expensive instruments and are only capable of detecting mutant strains comprising >20% of virus populations.
Patients were included if they were ≥18 years of age and had a confirmed diagnosis of CF based on genetic testing showing two CF-causing mutations and/or two documented sweet chloride values >60 mEq/L.
