Sentence examples for based on nonsynonymous mutations from inspiring English sources

On the other hand, because we identify mutation clusters purely based on nonsynonymous mutations, post-hoc testing for elevated dN/dS in cluster regions suffers from ascertainment bias.

Based on nonsynonymous (N) and synonymous (S) substitutions analysis, our results confirmed that purifying selection was the predominant force during the evolution of human mtDNA.

However, substitution rates vary across the genome and between species that makes direct comparisons solely based on nonsynonymous substitutions difficult.

In this case, the evolutionary distance based on synonymous substitutions is expected to be greater than the distance based on nonsynonymous substitutions.

Summary statistics involving coding regions included numbers of synonymous (Ks) and nonsynonymous (Ka) substitutions, were calculated utilising the KaKs_Calculator1.2 software (MYN method) [ 52], and the number of protein variants based on nonsynonymous substitutions.

The pattern will differ, however, when other forms of selection act on nonsynonymous mutations.

In any case, this association suggests that some selection is still acting on both codon usage and on nonsynonymous mutations in these regions.

A reduced Ne implies that the efficacy of selection on nonsynonymous mutations should be reduced in a highly inbred species relative to closely related outcrossing sibling species.

Table 5 lists the mutations identified; Line A includes one nonsynonymous mutation and one synonymous mutation and Line B includes two nonsynonymous mutations.

The tree is based only on the nonsynonymous mutations, and all mutations weighted equally.

The phylogenetic tree shown in Figure 1 is based on the number of nonsynonymous mutations the P450 variants have relative to the R-11 neutral evolution parent.