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The virus cripples enzymes vital for the function of the mitochondria, the cell's energy source.

Thus, the role of Hcp homologs is vital for the function of T6SS.

Moreover, unlike all other arginine residues, which could be mutated to lysines without impairing function, residues corresponding to R45 and R269 in a homologous protein (UhpT) were shown to be vital for the function.

In this unique case, the missense mutation c.1,124G>A, p.G375D (NM_001024218), abolishes both functions of gephyrin without affecting the structure and folding of the protein: (i) gephyrin‐G375D postsynaptic clustering and thus GABAergic synapse function is severely impaired and (ii) gephyrin‐G375D is unable to synthesize the molybdenum cofactor, which is vital for the function of molybdo enzymes.

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Extracellular calcium is vital for the functioning of many metabolic processes and neuromuscular activities.

Decurions were so vital for the functioning of cities that in the later Empire, as the ranks of the town councils became depleted, those who had risen to the Senate were encouraged by the central government to give up their seats and return to their hometowns, in an effort to sustain civic life.

The most extensively studied member of the IκB family is IκBα, which is vital for controlling the function of the prototypical NF-κB dimer, RelA/p50 [ 11].

The robust representation of the environment from unreliable sensory cues is vital for the efficient function of the brain.

This caspase-mediated PARP1 inactivation suggests that blocking PARP1 activity is vital for the proper function of the apoptotic machinery by the ensuing DNA fragmentation [ 11].

Thus, opening and closing of the binding cavity are vital for the shuttling function of FABP4, which controls access and egress of ligands and water molecules.

Interprofessional Collaboration (IPC) is a process evolving through interplay where each profession participates with their expertise and negotiates an understanding vital for the teams' function [ 1].

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