It is interesting to note, however, that the PWWP domain of LEDGF is critical for the function of the MLL in chromatin [ 70] and that the functional association of the LEDGF-PWWP domain with MLL at Hox genes mimics the naturally occurring arrangement of a PWWP domain at the N-terminus of the plant trithorax homologs, ATX1/2.
According to a recent study the enzymatic activity of MIF itself does not influence the biological functionality, but the conformation of the enzymatic domain is critical for the function of MIF [ 35].
Tetramer formation is critical for the function of p53.
Antibody-antigen (Ab-Ag) interaction is critical for the function of mAbs.
Oligomerization is postulated to be critical for the function of APOBEC3G.
The correct amount of potassium is critical for the function of nerve and muscles in the body, including your heart muscle.
The claudins constitute a 24-member family of proteins that are critical for the function and formation of tight junctions.
Transport of macromolecules between the cytoplasm and the nucleus is critical for the function of all eukaryotic cells.
Acetylcholinesterase is a key enzyme for levels of acetylcholine, which is critical for the function of the peripheral and central nervous systems.
Vesicular trafficking is critical for the function of bone cells, exemplified by bone diseases such as osteopetrosis, which frequently results from defects in this process.
TFIID subunit TAFII5 has been shown to be present twice in this complex and to be critical for the function and assembly of TFIID.
