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Inter-ring allosteric communication thus appears indispensable for the function of GroEL, and an engineered single-ring version (SR1) cannot substitute for GroEL in vivo.
As the adenylate cyclase enzyme encoded by the cya gene catalyzes formation of cAMP, which is indispensable for the function of CRP, we also constructed a cya deficient mutant and analyzed the level of Hcp.
These findings suggest that RXRα is indispensable for the function of PPARα, FXR, LXR and PXR in the mouse liver.
In particular, the expression of p66Shc is indispensable for the function of the p53 isoform (p44/p53) to induce of G2/M cell cycle arrest, after oxidative stress.
It is therefore very likely that at least some of the conserved residues are indispensable for the function of the LytR-CpsA-Psr domain in these proteins.
Modern research revealed clearly that gravity is important, probably indispensable for the function of living systems, from unicellular organisms to men.
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In some cases, before specific development projects or programs can succeed, aid is needed to help countries build the institutions that are indispensable for the functioning of nation-states.
However, Rammelsberg et. al. reported that none of the residues involved are completely indispensable for the functioning of the proton pump [ 78].
The BLSOM analyzing oligopeptide composition, therefore, appears to be positioned near with the functional motif searches, such as PRINTS and PROSITE, which are powerful, indispensable methods for the function prediction of proteins.
In addition, ADAMs 1 and 2 (fertilins) may be involved in sperm oocyte fusions, but do not seem indispensable for this function and, in man, the fertilin alpha gene is dysfunctional (Chen and Olson 2005; Cho et al. 1997, 1998, Evans et al. 1998; Jury et al. 1997, 1998).
The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain.
More suggestions(18)
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instrumental for the function
indispensable for the enjoyment
critical for the function
indispensable for the organization
indispensable for the performance
indispensable for the practice
vital for the function
indispensible for the function
indispensable for the alignment
prerequisite for the function
require for the function
imperative for the function
indispensable for the surface
indispensable for the design
indispensable for the display
indispensable for the induction
indispensable for the intelligibility
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Justyna Jupowicz-Kozak
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