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We then ask whether such mutations can spread in the population.
Thus, we demonstrate that proliferation is the key driver of somatic stem cell behavior and provide a model for how oncogenic mutations can spread throughout a stem cell pool by exploiting a fundamental homeostatic process of stochastic stem cell replacement.
doi: 10.7554/eLife.05899 Image Beneficial mutations can spread quickly via gene conversion to multiple locations in a genome Natural selection means that an individual with a beneficial mutation is more likely to pass on its genes to its offspring.
Thus bad mutations acting at young age can hardly spread in the population due to Darwinian selection pressure; for mutations acting at old age this pressure is much weaker, and these mutations can spread widely.
Similar to CTL escape mutations, drug resistance mutations can spread through the viral population within weeks and longitudinal sequence data has been used to study emergence and fitness cost of resistance mutations (Hedskog et al., 2010; Little et al., 2008; Paredes et al., 2009).
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However, beneficial mutations can also spread 'horizontally' so that they are shared between two (or more) locations in the genome of an individual.
This suggests that mutations acquired in a monomer can spread through an array, most likely via complex gene conversion mechanisms as has been described for other satellite DNA [31].
Of course, gene conversion can work in both directions; that is to say, the process can spread a mutation or reverse it.
This transfer can spread advantageous variation and remove deleterious mutations [ 9, 10].
Indeed, locally heteroplasmic mutations that alter this complex interaction can spread with age and impair cellular and tissues homeostasis.
He can spread the love.
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