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Exact(6)
We estimate that these mutations are partially additive (h ~ 0.3) in females.
It is possible that inherited or somatically acquired mtDNA mutations are partially or wholly responsible for this effect.
The dominance theory assumes that mutations are (partially) recessive and thus masked by heterozygosity (Turelli and Orr, 1995).
In the MA lines, we found a positive association between homozygous and heterozygous female fitness values suggesting that new mutations are partially additive.
As with the alternative mutations in PCHAS_011370, we suggest that these two alternative ubp1 mutations are partially selected (by CQ treatment) in the uncloned parasite AS-15CQ.
It is possible that these mutations are partially misfolded or unstable and are hence not properly recognized by the upstream protein kinase that phosphorylates the Ser and Ser residues.
Similar(54)
Signaling in T-ALL cell lines bearing class I mutations is partially refractory to inhibitory antibodies as compared to cell-penetrating gamma-secretase inhibitors.
The greater separation of spindle poles in the mutant cells would be readily explained if the smc3AAA mutations were partially dominant over SMC3-HA3 in cells that express (only) Smc1DD, giving rise to sub-lethal cohesion defects.
When it came to persistence of those in the genome over generations, however, he considered that all mutations were partially dominant (i.e. co-recessive, see table 1), and that even the most recessive deleterious mutations must have some slight effect (2 to 5%) on reproductive fitness [ 28].
We therefore suggest that both the T719N and I102del mutations were partially selected by intermediate levels of CQ in AS-15CQ prior to fixation during treatment with CQ (AS-30CQ), mefloquine (AS-15MF) or artesunate (AS-ATN) and subsequent cloning (Additional File 1, section 3).
These results indicate that the effects from the bub-1 mutation are partially suppressed by the mutation of fzy-1/CDC20, consistent with fzy-1 acting downstream of bub-1.
Related(17)
developments are partially
mutations are completely
mutations are totally
variants are partially
mutations are particularly
mutations are locally
mutations are entirely
mutations are largely
mutations are sometimes
mutations are slightly
mutations are incompletely
mutants are partially
variations are partially
mutations are fully
mutations are somewhat
mutations affect partially
mutations are selectively
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