Sentence examples for mutations are selectively from inspiring English sources
Vertical transmission of HIV-1 variants resistant to reverse transcriptase inhibitors has been reported and some studies suggest that resistant mutations are selectively transmitted [3] [5].
However, it is clear that proteins having deleterious mutations are selectively controlled by the protein degradation system to protect against misfolded or damaged proteins [45] and sometimes those mutations are compensated in other species [46].
The neutral theory of molecular evolution states that once a protein has evolved to a useful level of functionality the majority of mutations are selectively neutral at the molecular level and do not affect the function and folding of the protein whereas those mutations which are deleterious (loss of function or misfolding) provide selection pressure for residue conservation [10].
Substitutions that result in synonymous mutations are selectively neutral.
The authors appear to assume that synonymous mutations are selectively neutral.
Transcripts with nonsense mutations are selectively degraded by the NMD pathway during translation [ 5].
These data reflect that mutator mutations were selectively neutral, and consequently that mutator clones formed only after mutator mutations had hitchhiked to prominence on the back of clonal expansions driven by the selected driver mutations.
Missense mutations were selectively neutral and often gradually drifted towards homoplasmy over time.
However, the discovery that cells and tumour xenografts defective in homologous recombination DNA repair, including BRCA1 and BRCA2 mutations, were selectively killed by PARPi (Bryant et al, 2005; Farmer et al, 2005) led to a heightened interest in PARPi as single agents.
Our data shows that tumors with HER2 amplification or PIK3CA mutation are selectively dependent on Akt signaling compared to tumors in which the pathway is not mutationally activated.
Many families that carry the germline R337H mutation are selectively predisposed to childhood ACT [ 4, 6], although some appear to be at higher risk of more diverse cancers, including breast tumors and possibly other LF spectrum neoplasms such as brain tumors.
