Sentence examples for mutational target of from inspiring English sources

The high prevalence of TP53 mutations in hereditary [20] and sporadic [38] ovarian carcinomas suggests that this gene is a frequent mutational target of the selective pressure for aneuploid cells to overcome this checkpoint.

The mutational target of SCLs is the original stop codon.

This is mainly due to the much smaller mutational target of the mitochondrial genome.

The higher frequency of purR mutants was consistent with the larger mutational target of purR (∼1000 bp) compared to purO (16 bp).

Subsequent analysis has shown that these strains harbor a variety of sequence differences relative to N2 as a result of possible laboratory evolution (McGrath et al. 2009; Weber et al. 2010; McGrath et al. 2011), and our results show that hermaphrodite mating frequency can be a labile trait, possibly because of a large mutational target of genes that regulate reproductive decision.

The mutational targets of PTCs are any codons that can mutate directly to a stop codon (one-step codons).

Mutational targeting of specific functionality in this region without perturbing other functional determinants is a design challenge.

The network representation of the GPM results in a mutational target size of 2n 1 because the edges between nodes can mutate (i.e., the relationship among the genes can change).

L can be interpreted as the mutational target size of selection, or more generally the number of possible beneficial mutations from a given starting genotype.

[Consider a "mutational target" density of a few per genome vs. >6 × 10 per genome (Table S1)] And once a shift has occurred, the newly chosen hotspot motif would become subject to the concentration-dependent rate kinetics of conversion and mutation that drive the motif to dynamic equilibrium in the genome.

Progression to a particular cancer subtype may require a smaller subset of all possible mutational targets for a general type of cancer (Fig 4).