Sentence examples for mutational spectra of from inspiring English sources
Previous studies have found little difference in the mutation rates or mutational spectra of mutL and mutS mutant strains (Schaaper and Dunn 1987).
Even though the biological significance of missense and silent mutations are uncertain, the mutational spectra of the APC gene may provide a more complete picture of impact and type of carcinogenic exposure.
Some of these cases had mutations in the amplified fragments and these mutations were included in evaluating the mutational spectra of the gene.
The KAM study is to the best of our knowledge the first study to evaluate the association between colorectal adenomas, APC mutations and smoking history, and also to evaluate the complete mutational spectra of APC in CRC cases in relation to smoking history.
The mutational spectra of the APC gene revealed no difference in frequencies of mutations in cases based on ever and never smoking status.
The study was designed to detect mutational spectra of BRCA1/2 genes in a Serbian population.
The CAN1 marker used as a primary screen for mutator alleles has been sequenced extensively to describe the mutational spectrum of mutator alleles (Huang et al. 2003).
The mutational spectrum of these mutations has recently been described (Lee et al. 2012).
A total of 159 mutated positions relative to the reference sequence [40] were detected and analyzed in the network, including 104 nucleotide changes in the coding regions: the count of each kind of mutation is important in order to understand the mutational spectrum of the molecule and identify mutational hotspots.
With 35 independent synonymous mutations, we were also able to examine the mutational spectrum of base substitutions.
In conclusion, our previous and present results support that deleterious intragenic rearrangements in MEFV, MVK, NLRP3 and TNFRSF1A are rare or absent from the mutational spectrum of hereditary recurrent fevers, suggesting that other mutations in seemingly affected patients should be searched for either in other gene regions (e.g. promoter and introns) or in other candidate genes.
