In this case, mutational inactivation of the exonuclease should elevate mutation rates.
In this malignancy, mutational inactivation of FBXW7/hCDC4 in combination with NOTCH1 mutations predicts a favorable outcome [ 15, 47].
Point mutational inactivation of the retinoblastoma antioncogene.
Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors.
Indeed, mutational inactivation of TFEB induced increased mitochondrial damage, oxidative stress, tumor necrosis, and genomic instability that have been previously associated with suppressed autophagy in other tumors46,47,48,49.
Mutational inactivation of cooperativity therefore does not compromise the cell-cycle arrest response but strongly reduces binding of p53 to multiple proapoptotic gene promoters (BAX, PUMA, NOXA, CASP1).
Our strategy involved mutational inactivation of the MsbB (LpxM) lipid A acyltransferase to generate OMVs of reduced endotoxicity from Escherichia coli (E. coli) O157 H7.
MDM2 hyperactivity, due to amplification/overexpression or mutational inactivation of the ARF locus, inhibits the function of wild-type p53 and can lead to the development of a wide variety of cancers.
Conclusions: Mutational inactivation of PTEN does not play a major role in uterine sarcoma tumorigenesis, and another gene or genes on chromosome 10q may be implicated as a cause of these cancers.
These results confirm that mutational inactivation of p16INK4 is a rare event in tumor samples with compromised Rb activity.
Mutational inactivation of the Hh pathway has been demonstrated in human malignancies of the skin, cerebellum, and skeletal muscle.
