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Serero, A., Jubin, C., Loeillet, S., Legoix-Ne, P. & Nicolas, A. G. Mutational landscape of yeast mutator strains.
This map reveals the overall mutational landscape of genes mutated in colon cancer patients.
Moreover, we also show that the selection pressure induced by the treatment leads to the appearance of new mutations, which change the mutational landscape of the protein.
Results from these four wild-type strains were also used to compare the mutational landscape of wild-type and mutator strains (Serero et al. 2014).
Recent sequencing efforts describing the mutational landscape of medulloblastoma have identified mutations in histone demethylating enzymes predominantly in G3 and G4 tumors [ 10].
Indeed, multiple neutral changes along the mutational landscape of a protein may precede mutations with high advantageous fitness effect [ 27].
To our knowledge, this is the first published report detailing the mutational landscape of these diseases and the first description of a potential driver mutation in pediatric-type follicular lymphoma.
Herein, we review our current knowledge of the mutational landscape of human prostate cancer, describing what is known of the common mutations underpinning its development.
Extended Data Fig. 1 Mutational landscape of patient GBM tumours.
Grasso, C. S. et al. The mutational landscape of lethal castration-resistant prostate cancer.
Pickering, C. R. et al. Mutational landscape of aggressive cutaneous squamous cell carcinoma.
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