Sentence examples for mutation to glutamine from inspiring English sources

On the other hand, mutation to glutamine, asparagine, or alanine produces receptors that are expressed on the cell surface, but decreases receptor affinity for the competitive antagonist d-tubocurarine (dTC) 5-35-fold.

The second N-glycosylation consensus site was removed in KCNE2 by mutation to glutamine (N29Q).

Surprisingly, the histidine is not on the dimer interface but its mutation to glutamine or lysine partly or fully recapitulates low pH behavior both in the context of the ACD dimer and in oligomers.

Residue Glu217 is the required proton donor to the scissile glycosidic bond that leads to the reactive oxocarbenium species; hence, its conservative mutation to glutamine abrogates its catalytic activity.

Further bolstering the case for Glu222 as the principal coupled ionizable site is the fact that upon mutation to glutamine (E222Q) the thermodynamic signature of any coupling is eliminated (see section S.9 of the Supporting Information for details).

One of the studies found that mutation of E286 to alanine led to an increase in KM for pterin, while mutation to glutamine did not change the KM of pterin.

The single missense mutation, arginine 225 to glutamine (R225Q) results in a dominant mutation that is homologous to the γ3 R225W variant described here.

Mutation of Glu11 to glutamine abolishes putrescine activation of processing (34), and mutation to aspartate causes putrescine to be an inhibitor of processing (23).

Mutation of Lys49 to glutamine (K49E) results in a >200-fold reduction in binding affinity (K D  = 120.48 ± 5.72 μmol/L) due to the electrostatic repulsion between two electronegative side chains (Fig. 5B).

The myosin point mutation of Arg403 to glutamine (R403Q) causes one of the most severe phenotypes of FHC.

For example, the mutation of lysine to glutamine in eIF-4A protein resulted in severely reduced ATP binding, and complete loss of ATPase activity [24].