Sentence examples for mutation to disrupt from inspiring English sources

Introducing a proline mutation to disrupt this putative helix drastically increases the autolytic properties of IS1.

As the Iowa mutation does not alter the hydrophobic character of Aβ (1 40), the reduced ability of the Iowa mutation to disrupt supported lipid bilayers appears to be related to eliminating a negative charge from the peptide.

More extensive mutation to disrupt both sites further compromised regulation by miR-965.

For each candidate for causality, it is desirable to assess the potential for the sequence mutation to disrupt a biological function.

Knockout mice were made by using an insertion mutation to disrupt the Cln3 gene, whereby Cln3 exon 1 6 including the start methionine is replaced by a neomycin selectable marker cassette to create a null allele (57, 58).

For example, the β-barrel structure of the hNck2 SH3 domain could transform into a similar helical conformation triggered by either acid-induced unfolding or mutation to disrupt tertiary interactions.

We have designed point mutations to disrupt the longitudinal interfaces bonding subunits into protofilaments.

Based on the atomic interactions between RB and E2F amino acids, we constructed several mutations to disrupt this E2F-binding pocket.

To confirm that the rescued growth and WGA binding phenotypes observed in och1Δ[LOC-MyoD][Id2-CAT] yeare are due to the interaction between MyoD and Id2, we designed mutations to disrupt this interaction.

In this study, we re-examined the effect of VHL missense mutations to disrupt the formation of the VBC complex, and demonstrate that characteristic Type 2B VHL mutations form a low-abundance VBC complex which retains the ability to ubiquitylate HIF-1α.

However, neither mutations to disrupt the intro/exon sequence nor non-sense mutations in exon 3 was found (data not shown).