Sentence examples for mutation or disruption from inspiring English sources

As a critical tumor suppressor, p53 is inactivated in human cancer cells by somatic gene mutation or disruption of pathways required for its activation.

p53 is critical to suppress cancer development in humans, and the loss of wild-type p53 activity through direct somatic gene mutation or disruption of pathways important for p53 activation is required for cancer progression (Vousden and Prives, 2009).

Since Dicer is required for processing of almost all mature miRNAs, mutation or disruption of Dicer has been widely used as an approach to investigate the biological significance of miRNAs in various cell types including cardiomyocytes [17] [19], endothelial cells [20] [22], fibroblasts [23] and immune cells 24 26].

Therefore, it was clear that intracellular cellobiase activity was affected by bgl2 mutation or disruption.

The cell biomass of these strains was comparable when cultivated on cellobiose, indicating the absence of any influence of the bgl2 mutation or disruption (data not shown).

These remote enhancers can be essential for gene expression, as shown by human disorders resulting from their mutation or disruption by chromosomal rearrangements [ 12- 16].

By first assigning mutations or disruptions to a linkage group, recombination of unlinked properties can be achieved in an orchestrated manner (Swart et al. 1990; van den Hombergh et al. 1997).

They're beautiful, although one might wish for a conceptual glitch or a formal mutation, or the disruption of a rogue rhizome.

Given the observation that even apparently normal mucosa in patients with HPS is highly methylated [6], we investigated the potential for mutation or epigenetic disruption of DNMT1 (CCDNMT3A8.1), DNMT3B (CCDS1718.1), DNMT3B (CCDS13204.1) and DNMT3L (CCDS13705.1) in the development of HPS.

The critical tumor suppression activity of p53 is underscored by the finding that p53 is inactivated in most human cancers either by gene mutation or the disruption of pathways required for p53 activation [ 109].

Mutations in p53, or disruption of the pathways that allow activation of p53, seem to be a general feature of all cancers.