Sentence examples for mutation or amplification from inspiring English sources

The RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification.

Now a new study shows that this resistance can be caused by either mutation or amplification of the gene that makes the drug's target.

The target gene itself can be altered by mutation or amplification, thus limiting the ability of the drug to inhibit activity of the kinase that remains active and drives aberrant signaling.

Extensive pre-clinical and clinical data have demonstrated that single agent targeted therapies lead to modest single agent activity of generally limited duration, even in the setting of innate PI3K pathway activation via mutation or amplification.

Furthermore, additional studies, although limited, suggest that heightened expression in these tumors is not due to mutation or amplification of the gene.

Point mutation or amplification of the α-synuclein gene causes PD, in which melanin-positive, dopaminergic neurons of the substantia nigra are degenerated [13].

The presence of AR expression, somatic AR mutations or amplification does not necessarily mean, however, that a prostate cancer cell is addicted to AR signaling.

We propose that other tumors that possess somatic autoactivating mutations or amplification in non-receptor tyrosine kinases could use similar mechanisms for AKT activation [37].

Oncogenic mutations or amplification of Ras results in VEGF upregulation.

The Kaplan-Meier method was used for survival analysis grouping with PIK3CA mutations or amplification.

Tumour tissues from GEFCAPI 01 are not available to study other molecular markers such as Her-2 amplification, c-Kit mutations, or EGFR mutations or amplification.