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However, the reason why a particular mutation, or combination of mutations, stabilizes the receptor is not always evident from a static crystal structure.
However, each tumor harbored only a few mutations, and no single mutation or combination of mutations predominated across the tumor samples [18].
Third, GBA approaches often generate implicit predictions of gene function without providing explicit predictions of the effects of a mutation or combination of mutations, thereby limiting the power to generate directly testable hypotheses.
To identify which mutation or combination of mutations was transferred from M184 to the three transformants to give patAB overexpression, the whole genomes of the transformants were sequenced by Illumina sequencing.
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An online interface is available for evaluating any human gene mutation or combinations of maximum three such genes (http://www.g-2-o.com).
The registration-free, online interface of the Genotype To Outcome (http://www.g-2-o.com) web server enables researchers, bioinformaticians, and clinicians to query the genetic background of a patient by performing an express evaluation of a discovered mutation, or combinations of mutations for any gene.
Examples of CV1 differences are shown for each comparison in Figure 3. Nanoarray detection followed by DFA analysis proved to have significant specificity and sensitivity for: KRAS mutation (with or without additional TP53 knockdown); TP53 knockdown (with or without additional KRAS mutation); or combinations of mutations.
If the association holds up in larger studies, Chatila says, doctors could use the information to sort out which mutation--or combination of mutations--leads to different kinds of allergic diseases.
Approximately 200 variant alleles have been described and 140 mutations, or combination of mutations, have been identified [2].
If a trait only arises from a limited number of specific mutations or combination of mutations, then experimentally delineating these mutations would be helpful for surveillance.
Coat and plumage colours result from the interplay of a number of genes, and the variety of visible colours associated with specific mutations or combination of mutations may be used to gain an insight into underlying gene action.
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