Sentence examples for mutation or fusion from inspiring English sources

Oncogenic activation via mutation or fusion often disrupts inactivating geometries.

Commonly accepted endpoints in clinical research for both nonmetastatic and metastatic breast cancer patients are detailed in Box 1. Technically, as most carcinomas do not have specific and recurrent DNA mutation or fusion transcripts, CTC isolation methods rely on the detection of cells that express epithelial-related markers in blood.

Notably, mutations of epigenetic modifier genes (EMGs), such as DNMT3A (0.3%), TET2 (4.5%), IDH1 (0.4%), IDH2 (0.2%) and ASXL1 (1.6%), could co-exist with PML– RARα fusion, whereas no PTD mutation or fusion of MLL was noted in any cases, suggesting a mutual exclusivity between MLL abnormalities and the PML– RARα characteristic of APL.

JAK2 mutations or fusion proteins leading to constitutive activation of JAK2 have long been known to have a role in MPNs and leukemia.

Key advantages over earlier TCR expression systems are the ability to produce "native" TCR sequences without previous engineering steps such as the introduction of solubility increasing mutations or fusion proteins and the ability to generate soluble material without refolding strategies.

Mutations or fusions of both EGFR and ALK may be primary causes of cancer, whereas both the EGFR gatekeeper mutant T190M and MET may generate drug resistance.

Recently it has been revealed that lung adenocarcinomas with distinct gene mutations or fusions are associated with particular histopathological entities.

Moreover, the response of CNS tumors with alternative BRAF abnormalities, such as alternate V600 mutations or fusions, will also need to be investigated.

Recent advances in molecular genomic analyses of lung adenocarcinoma specimens have revealed recurrent association of distinct gene mutations or fusions with particular clinicopathological entities [ 3].

Other studies have uncovered mutations or fusions of other genes such as IDH1/IDH2 and FGFR, respectively, in subsets of GBM patients.

The following search criteria were used: [lung OR non small cell lung OR NSCLC] AND [adeno* OR squamous] AND [tumour OR tumor] AND [mutation* OR fusion OR translocation].