Sentence examples for mutation or binding from inspiring English sources

It is inactivated by mutation or binding with human double minute 2 (HDM2) protein.

Folding and/or unfolding as a result of pressure, chromatography, carboxyl-group modification, mutation, or binding were also explored in recent publications.

Lack of arrest in G1 was not related to p53 mutation or binding to SV40 Tag, except in one HMCL presenting a missense mutation at codon 248.

Aberrant AR activity, promoted by mutations or binding partner misregulation, can present as many clinical manifestations including androgen insensitivity syndrome and prostate cancer.

Our finding that Rbf1 can interact with chromosomal proteins like ORC regardless of E2F association gives fresh insight into the tumor suppressive properties of retinoblastoma proteins, since they may retain the potential to regulate cellular events, such as replication initiation, even while E2F binding to RB is inhibited by mutation, phosphorylation, or binding of viral oncoproteins [18].

Many studies have mapped correlated motions and their perturbations due to mutation or ligand binding onto structures to link structural and thermodynamic changes [ 57, 65, 66].

We show the increased amenity to polymerization by either the pathogenic E342K mutation or the binding of mAb5E3 occurs without affecting the energetic barrier to polymerization.

Removal of the IL from the allosteric site, either by mutation [ 8] or binding of substrate is sufficient to allow active site formation.

Constitutively activating mutations or agonist binding disrupts such constraining interactions leading to receptor conformations that associates with and activate G-proteins.

Thus, altered presentation of the APP substrate to γ-secretase, driven by either APP mutations or by binding of the pharmacological agents to APP could, in turn, allosterically affect PS1 conformation.

This marker is 1496 base pairs downstream of PTPN22 where the polymorphism results in either a synonymous mutation or putative transcription binding site.