Sentence examples for mutants that include from inspiring English sources

SOX4 mutants that include the K95R point mutation did not restore SOX4 transcriptional activity.

In contrast, SOX4 mutants that include the K45R mutation did restore the transcriptional activity of SOX4, which demonstrates the importance of SOX4 acetylation at Lys95 residue.

Improvements in the production of transgenic mice led to the creation of knock-in mice expressing various hotspot mutants that include structural or DNA contact mutants and result in more 'human-like' tumors.

That is, double mutants that include mutations that are relatively "good mixers" tend to be more fit than double mutants that harbour "bad mixers", even when the identity of their partner mutations is held constant.

For the SBE genes (Table 3) we have identified and selected mutants that include splice junction mutations, a premature stop codon and several missense mutations that are predicted to have an effect on SBE protein activity.

To test this idea, we generated a set of luciferase reporter constructs to compare the activity of a 3.1 kb 5' flanking region of FSCN1 (comprising the region −2956/+114) with truncation mutants that included or deleted either or both of regions A and B, or separated these regions from the distal conserved motifs.

In addition to double-mutant mice of FA core complex genes, double mutants that included Fancd2 knockout have been generated.

We computed single mutant scores by averaging across all scores of double mutants that included mutations of the corresponding genes.

This group also determined that PRIMA-1 could restore DNA binding in electromobility shift assays to a wide array of mutants that included both DNA contact (R248, R273) and conformational mutants (R175H) [ 31].

This new system allowed us to obtain a whole family of mutants that included the cross-inactivated variants together with an extended set of control forms to further analyze electronic communication between two hemes bL.

Reporter activity was not further decreased in a quadruple mutant that included the motif 1 mutation (Fig. 5B).