Sentence examples for mutants that confer from inspiring English sources
Among the limited number of M2 mutants that confer amantadine resistance, the M2-V27A mutant was found to be the predominant mutant under drug selection pressure, thereby representing a high profile antiviral drug target.
To do this, we developed a screen for ftsZ mutants that confer insensitivity to MinC.
The main goal of the induction regimen is to decrease the abundance of randomly generated mutants that confer resistance to the maintenance regimen, thereby increasing subsequent treatment success.
In total, we found three FtsZ mutants that confer resistance to MinCD overproduction, and we characterized the effect of MinC on the mutants in vitro.
While the total virus population is temporarily shrinking, mutants that confer resistance against a potential follow-up treatment (red line, dark grey shaded area in Fig. 2B) are depleted (possibly eradicated).
Therefore, at the time of treatment change (vertical dashed black line in Fig. 2D), total virus has been decreased and mutants that confer resistance to the maintenance therapy (red line, dark grey shaded area in Fig. 2D) are likely to be eradicated, which improves the probability to achieve durable virological suppression with the maintenance therapy.
Specific mutants that conferred increased growth in mixed sugars and hydrolysate tolerance conditions were isolated, confirmed, and evaluated for changes in genome-wide expression levels.
To test if the irrE mutants that conferred higher alcohol tolerances could decrease intracellular ROS levels in E. coli cells under alcohol stress, we performed ROS assays with two representative alcohol resistant mutants of irrE: ethanol-tolerant mutant E1 and butanol-tolerant mutant B29.
Additionally, there is a second binding site on the protease surface of a V32I drug-resistant mutant that confers additional activity for DRV, in contrast to older agents.
However, during viral rebound the total viral population re-expands and consequently erroneous reverse transcription generates novel mutants that can confer resistance against a second line therapy.
The malignant cells are characterized by chromosomal alterations leading to the expression of mutant proteins that confer survival and proliferation advantages.
