fHbp vaccination may select for mutants that do not require fHbp for complement evasion.
When constructing genetically engineered model organisms, it will be important to make mutants that do not trigger NITC, to avoid biological defects being masked.
These results will allow the design of LSP1 mutants that do not bind to the cytoskeleton to determine the importance of LSP1 cytoskeleton binding for the diverse functions of LSP1.
In order to find the physiological substrates of these enzymes, diverse PTP mutants that do not possess any catalytic activities but appear to bind tightly to their tyrosine phosphorylated substrates have been designed.
Here, we ask whether orientational ordering of helix-forming segments occurs early on during folding of a downhill λ6 85 mutant, and how much it correlates with the thermodynamics and kinetics of various λ6 85 mutants that do have folding barriers.
Here we present the analysis of seven insertional mutants that do not undergo normal bradyzoite differentiation.
Such tolerance may underlie evolutionary pressure, since PrPC mutants that do not undergo α-cleavage are neurotoxic [14], [15], [16].
We present the analysis of seven novel T. gondii insertional mutants that do not undergo normal differentiation to bradyzoites.
Notably, MyoD deletion mutants that do not interact with Runx1 do not interact with CBFβ (Figure 2A).
To determine if Hsc70 was relocalized to nuclear foci during infection with ICP27 mutants that do not interact with Hsc70, immunofluorescent staining was performed.
