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Why do Smc1 M665R and Smc3 mutantmutant proteins fail to confer sister chromatid cohesion?
Ndc80 loop mutant proteins fail to recruit Dis1 to kinetochores, imposing unstable attachment and frequent spindle collapse.
However, concerns were raised by reviewers that this does not account for the possibility that mutant proteins fail to reach the cell surface.
In addition, the translocation of Parkin to mitochondria has etiological significance, as a number of disease-associated Parkin mutant proteins fail to translocate.
However, concerns were raised by the reviewers that this does not account for the possibility that mutant proteins fail to reach the cell surface.
In Cx32, mutations of Arg75 (R75P, R75W, R75W) associated with X-linked Charcot Marie Tooth disease (CMT1X) result in trafficking problems, and mutant proteins fail to reach the plasma membrane [21].
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We found that even when TagSpoIIE was removed, the mutant proteins failed to activate σF.
In the absence of nucleotide, wild-type Hsp104 and most of the mutant proteins failed to hexamerize.
Spc1101 220-5D-CM1-QA and Spc1101 220-5D-CM1-QAutand proteinSpc1101 220-5D-ΔSPMe γ-TuSpc1101 220-5D-ΔSPMeven when the five activating Cdk1 and mutantutations were proteins
Even more intriguing, the team discovered that the mutant protein failed to stop cells from spewing calcium into the valve cells of mouse heart tissue.
The fab1-2 mutant protein fails to localize to the vacuole membrane.
Related(20)
mutant cells fail
mutant proteins lost
mutant proteins failed
mutant worms fail
mutant embryos fail
mutant mice fail
mutant disks fail
mutant alleles fail
mutant plants fail
mutant neuroblasts fail
mutant bacteria fail
mutant females fail
mutant larvae fail
mutant proteins are
mutant males fail
mutant GMCs fail
mutant parasites fail
mutant forms fail
mutant blastocysts fail
mutant animals fail
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