Sentence examples for mutant blastocysts fail from inspiring English sources

Mbd3 is essential for early embryogenesis and in culture, Mbd3 mutant blastocysts fail to proliferate [ 36 ].

Cell proliferation defect is also evident in vitro, where mutant blastocysts in culture fail to give rise to typical colonies formed by inner cell mass.

In culture, Ubc9 mutant blastocysts are viable, but fail to expand after 2 days and show apoptosis of the inner cell mass.

The homozygous Pold1−/− mutant blastocysts were morphologically indistinguishable from wild-type and heterozygous embryos (Fig. 2A).

Subsequently, however, the growth of both trophoblast giant cells and inner cell mass in all mutant blastocysts (n = 6) slowed down significantly compared with controls.

During the first two days in vitro, both control and mutant blastocysts exhibited substantial trophoblast giant cell outgrowth and inner cell mass growth (Figure 5A2 and 5B2).

Here we injected iPSCs into mdx single mutant and mdx∶utrophin double mutant blastocysts, to generate a mosaic rescue paradigm and to study the corrective potential of the iPSCs in mild and severe mouse models of DMD.

Therefore, we carefully scrutinised lineage segregation in mutant blastocysts by immunohistochemistry.

XEN cells isolated from Nodal mutant blastocysts showed a surprising upregulation of AVE markers.

Although NANOG expression was predominantly localised to the ICM in both wild-type and mutant blastocysts, Chd4 mutant blastocysts contained more NANOG-expressing cells than did wild-type or heterozygous littermates.

In the absence of a functional TE, Chd4 mutant blastocysts do not implant and are hence not viable.