Sentence examples for mutant is inactive from inspiring English sources

The CDK9 T186A mutant is inactive [28] and thus may act as dominant negative to inhibit HIV-1 transcription.

As the R6K mutant is inactive for CXCR2 receptor activation and does not recruit neutrophils, upregulation of KC must be due to activation of a non-canonical receptor in one or more cell types in the lung.

Thus, it appears paradoxical that the T261E mutant is inactive.

A Gly131Ser SalL mutant is inactive, but a Tyr70Thr/Gly131Ser double mutant actually improves SalL's chlorination and bromination activity while eliminating the iodination activity.

By analogy with the reduced RNA binding affinity to the yeast Has1p helicase with T/A or S/A substitution in motif III hydroxyls (SAT) [ 63], the reason why the TS/AA RIG-I mutant is inactive might be the reduced ability of hel to bind any RNA including self RNA.

Phe is a good substitute for Tyr 29, but the Y29P mutant was inactive.

In support of p27 lying downstream of AMPK on the activation of autophagy in Tsc2-null cells, a p27 mutant that preferentially localizes in the cytosol recovered the effect of rapamycin on autophagy in both p27- and LKB1-depleted cells, but a nuclear p27 mutant was inactive.

The PfPdx1 DKK (D26A/K83A/K151A) triple mutant enzyme as well as each individual mutant were inactive.

In hAFP, Thr98Ala mutant was inactive, whereas in sea raven AFP the corresponding residue is an Ala residue.

Whereas MT2-R138C was inactive in the ERK1/2 assay and the cAMP assay, the MT2-V124I mutant was inactive in the ERK1/2 assay but fully active in the cAMP assay (Figure 4B) indicating that the latter mutant is biased towards the cAMP pathway.

Although the G68C mutant was inactive in complementation, it cleaved the model substrate with a slightly lower but significant efficiency.