Sentence examples for multiple tumor tissues from inspiring English sources

The fact that PAK mutations are detected in multiple tumor tissues makes PAKs a novel therapeutic drug target.

Similarly, CA XII expression has been observed to be upregulated in multiple tumor tissues but it has not been established as a prognostic marker [ 74– 74].

To demonstrate that TRIM59 upregulation is tumor tissue specific in multiple tumor tissues, we have presented sufficient controls, including negative staining in most of normal tissues.

But this is not the goal of the present work, our goal is to identify and distinguish relevant features of multiple tumor tissues; we demonstrate that the proposed analysis is sensitive enough for this purpose.

Also iNOS, one of the three distinct isoforms of NOS which is widely expressed and often upregulated in multiple tumor tissues [ 57] is expressed in tumor cells associated with vascularization and hence, is probably another important regulator of angiogenesis [ 56, 57].

Our results demonstrated that expression of seven alternative splice variant mRNAs (VEGFR1, VEGFR3, Met, RAGE, Tie1, FGFR1, and Kit) is present in multiple normal and tumor tissues.

The downregulation of latexin expression in multiple tumor cell lines and tumor tissues suggests that latexin may be functionally involved in the suppression of cancer cell growth.

Although the low expression of BCCIP is observed in multiple clinically diagnosed primary tumor tissues such as ovarian cancer, renal cell carcinoma and colorectal carcinoma, the mechanism of how BCCIP is regulated in cells is still unclear.

Together with the reports described above, 4– 6, 35 it is supposed that GD3 expression enhances cell adhesion to the environmental connective tissues and raises the sensitivity to HGF supplied from the tumor microenvironment, resulting in the convergence of multiple extrinsic signals in tumor tissues.

Our new IVM study of multiple tumor types subjected to tissue co-implantation clearly shows that the tissue stroma can have a very significant and even dramatic effect on tumor growth and vascular development.

Thus, the orthotopic tissue could create for multiple tumor cell lines a local tissue microenvironment that favored tumor growth by promoting tumor-cell mitosis over apoptosis.