Harmine, a β-carboline alkaloid from Peganum harmala, has multiple anti-tumor activities, especially for its folk therapy for digestive system neoplasm.
We have previously shown that both variants of the protein the sEphB4 alone and sEphB4-HSA have anti-tumor activities in multiple tumor models [ 14, 28, 30].
TDG was very effective at suppressing tumor growth by inhibiting multiple tumor promoting and protective activities of tumor-derived galectin-1, including immune cell dysregulation, angiogenesis, and protection against oxidative stress.
OSI-027 was well-tolerated in vivo and demonstrated potent anti-tumor activity in multiple tumor xenografts models.
Our analysis of multiple tumor entities using these activity profiles resulted in a clearly structured functional cancer map (figure 2).
The most potent compound 8r showed slightly higher growth inhibitory activity than SAHA in multiple tumor cell lines, even though, antiproliferative activity of 8r seemed inferior to its HDAC inhibition activity.
Among these compounds, the most potent compound 9n exhibited similar if not better HDAC inhibition and antiproliferative activities against multiple tumor cell lines compared with the positive control entinostat (MS-275).
Indole-3-carbinol is a phytochemical found as a conjugate in cruciferous vegetables, and both indole-3-carbinol and one of its major metabolites, 3,3'-diindolylmethane (DIM), exhibit a broad range of anticancer and antitumorigenic activities against multiple tumor types [ 1- 6].
Toceranib also exhibited activity against multiple tumor types in the original phase 1 study, suggesting that the action of toceranib against receptors other than KIT may play a role in the responses observed in solid tumors [ 3].
Wip1 also suppresses the activity of multiple tumor suppressors, including p53, ATM, p16INK4a and ARF.
