Sentence examples for multiple tumor models from inspiring English sources

Compared with monospecific anti-HER antibodies, MEHD7945A was more broadly efficacious in multiple tumor models, showing that combined inhibition of EGFR and HER3 with a single antibody is beneficial.

Dose responsive tumor growth inhibition was observed in multiple tumor models (Fig. 6, Fig. 7).

2ME2 inhibits tumor-associated angiogenesis and malignant progression in multiple tumor models in the absence of dose-limiting toxicities.

23 Some evidence suggests that anti-PlGF antibodies are effective in inhibiting pathological angiogenesis across multiple tumor models.

Both of these cytokines have been demonstrated to drive the accumulation and suppressive function of MDSCs in multiple tumor models [ 54, 55].

Decreased numbers of mature DCs have been demonstrated in the circulation, tumor bed, and draining lymph nodes, in multiple tumor models.

Calorie restriction (CR), a reduced-calorie dietary regimen typically involving a 20 40% reduction in calorie consumption, prevents or reverses obesity, and inhibits mammary and other types of cancer in multiple tumor model systems.

OSI-027 was well-tolerated in vivo and demonstrated potent anti-tumor activity in multiple tumor xenografts models.

In particular, EPZ-5676, EPZ-6438, and GSK126 have demonstrated in vivo efficacy in multiple tumor xenograft models and have been advanced to clinic evaluation, highlighting the importance of chemical probes.

Further optimization of 7i to balance biochemical and cellular potencies with favorable ADME/ PK properties led to the identification of 8h, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.

AR-42 (previously called OSU-HDAC42) is a novel hydroxamate-tethered phenylbutyrate derivative [16], [17] with in vitro and in vivo activity in multiple solid tumor models [18], [19], [20], [21] and more recently, in mouse and canine mast cells [22].