Multiplicity analysis of somatic mutations could identify those with the highest multiplicity as those most likely to be effective molecular targets across multiple tumor types.
Here, we report that Notch signaling regulates the hypoxic response in multiple tumor types by controlling HIF2α expression.
Objective tumor responses to TLR9 agonist monotherapy have been observed in multiple tumor types, including both solid tumors and hematologic malignancies.
Willis, T.G. et al. Bcl10 is involved in t(1 14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.
Combined expression of IC proteins with CD73 or A2aR/A2bR in multiple tumor types presents an opportunity for novel combinatorial therapies.
This improved biologic understanding of the diseases we treat has led to unprecedented therapeutic breakthroughs across multiple tumor types.
Many different GPCR isoforms are enhanced or dysregulated in multiple tumor types, and several GPCRs have known oncogenic activity.
This emerging strategy has been used in unique ways to target multiple tumor types, including solid and haematological malignancies.
c-Met was emerging as an attractive target for cancer-targeted therapy because deregulation of c-Met has been observed in multiple tumor types.
Up-regulation of glycolysis has been demonstrated in multiple tumor types and is believed to originate as an adaptive response to the selective pressure of the tumor microenvironment.
The taxanes are among the most active cytotoxic agents in oncology and are widely used in adjuvant and advanced treatment settings in multiple tumor types.
