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Current evidence indicates that altered cell-matrix interactions in SSS have multiple negative effects on ECM assembly, TGF-β activity, cell identity and integrin signaling [ 37].
We show that senescent VSMCs establish an inflammatory SASP driven by IL-1α that may have multiple negative effects on atherosclerosis.
B cell lineages are now known to have multiple negative effects on the alloimmune response, including antigen presentation to T cells, the production of cytokines supporting T cell activation, antibody production and tertiary lymphoid organ and lymphatic vessel formation 140.
Mechanical ventilation plays a vital role in restoring and maintaining gas exchange in patients with respiratory failure, but can have multiple negative effects, jointly termed "ventilator-induced lung injury" (VILI).
68, 69 An increase in nutrients also can stimulate growth of macroalgae and turf algae, 70 which have been shown to have multiple negative effects on the coral microbiome, such as depletion of local oxygen concentrations, 37, 71, 72 transferal of allelotoxins, 73– 76 and transmission or vectoring of pathogens.
Further large-scaled, prospective study is warranted to evaluated the association among RRT intervention, cytokines/chemokines/oxidative stress, and remote organs injury, in AKI patients undergoing optimized RRT in a way that the multiple negative effects of the acute uremic state are mitigated.
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Parasite infections can influence maternal investment decisions due to their multiple negative physiological effects.
The former argues that multiple roles might have negative effects on women's psychological well-being, while the latter argues that engaging in multiple roles enhances women's mental well-being [ 18].
Jeff Conte, an associate professor of psychology at San Diego State University, and co-author of "Work in the 21st Century" (Wiley-Blackwell, 2010), said there had been little, if any, research on the issue of multiple layoffs and the negative effects.
We first sought to determine whether intellectual enrichment protects persons with multiple sclerosis from the negative effects of brain atrophy on cognitive status.
In contemporary developed populations, decades of research have identified stepfather presence to have negative effects on multiple child outcomes.
Related(20)
multiple deleterious effects
numerous negative effects
many negative effects
multiple damaging effects
various negative effects
multiple harmful effects
multiple undesirable effects
multiple detrimental effects
several negative effects
multiple negative selections
multiple neuroprotective effects
multiple untoward effects
multiple negative colonoscopies
multiple negative expressions
multiple negative controls
multiple negative correlations
multiple negative externalities
multiple negative biopsies
multiple negative feedbacks
multiple negative charges
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