Baseline Hsp27 WHC and after HC showed multiple, exclusively negative correlations with the evolution of GS, FR, GW and EMS in the placebo group.
Remarkably, adiponectin is the only adipocyte-specific protein that is known to be negatively regulated by obesity and to show insulin-sensitizing properties with strong negative correlations with multiple indices of insulin resistance (16).
Without correcting for multiple measurements, there were significant negative correlations between conscientiousness and trigeminal chemosensory perception sensitivity (r = −0.213, puncorr = 0.28) and with electrical cutaneous pain sensitivity (r = −0.181, puncorr = 0.46), but both correlations vanished on correction for multiple measurements.
After correction for multiple tests, we found significant negative correlations between disease duration and levels of anti-idiotypic IgM autoAbs reacting with hypocretin-1 IgG autoAbs (r = −0.39, p = 0.004) in all patients' groups combined.
After correction for multiple tests, we found significant negative correlations between disease duration and levels of hypocretin-1 free IgG autoAbs (r = −0.35, p = 0.013), and levels of hypocretin-1 free IgM autoAbs (r = −0.39, p = 0.003).
For multiple testing for the miRNA-mRNA (negative) correlations, we used a false discovery rate (FDR) approach [ 19]; we defined FDR < 0.05 as significant.
Negative correlations resulting from multiple species interactions on pairwise antagonistic co-evolution are mostly due to trade-offs between defence mechanisms against multiple enemies, where a benefit from a change in one life-history trait is overridden by the disadvantage introduced by a change in another trait in a given environment [ 15, 23].
Negative correlations were observed between multiple histological measures and the stride length residual and single-limb support residuals.
Using the Bonferroni correction for multiple tests, 7 miRNAs were found to show significantly more negative correlations with the predicted targets, while only two were found to show more positive correlation (Figure3).
The results of the simple correlation matrix differ considerably from the results provided by the multiple negative binomial regressions and the subsequent identification of commensalism and amensalism.
