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However, we are unsure if this was due to the pleiotropic action of a single gene or multiple linked genes [ 16, 32].
A QTL analysis typically produces a large confidence interval, and it is usually uncertain whether a QTL corresponds to one or multiple linked genes [ 10, 11].
The peak is much broader than those typically observed so it is conceivable this peak is associated with multiple linked genes.
The TDDs range in size from several kb to >1 Mb and thus can increase the copy number of multiple linked genes and their regulatory sequences.
Having to identify single genes, not extended regions with multiple linked genes as would be required for analysis of synteny, overcomes a practical difficulty that not all sequenced genomes have been completely assembled yet.
For the HGT events occurred in the MRCA of the Mirum clade and involving multiple linked genes (fig. 5), the donors were most likely those sharing similar ecological niches (e.g., arthropod guts) and genomic characteristics (e.g., low GC content and the associated biased codon usage preference) with the recipient.
Similar(53)
Furthermore, additional experiments with other strains suggest that sex determination may occur through the action of multiple alleles at one locus or multiple tightly linked genes (Olmstead A, personal communication).
Co-locating QTL regions could contain multiple tightly linked genes for resistance and other traits or single genes with a pleiotropic effect across multiple traits.
The frequent recovery of multiple different linked genes on genomic elements indicates a high density of coding sequences in this genome.
However, due to the absence of crossovers in the major part of each chromosome it is unclear that if these QTLs represent pleiotropic QTL having effects on multiple traits or closely linked genes.
We have also modified the Discussion to point out that the substantial size of the typical 16 kb freshwater haplotype may be due to coselection for multiple phenotypes arising from linked genes, and that NAKA may be an interesting example of a population that has fixed only the armor plate changes (see the end of paragraph 5 of the revised Discussion).
Related(20)
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