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Tga1 may represent one gene or several linked genes.
MQTL with large physical intervals may also contain several linked genes influencing the same trait.
Each LMW-GS allele was encoded by several linked genes or haplotypes [ 13, 14, 16, 17, 21, 22].
However, the QTL region is very large, and we also allow for the possibility that the QTL consists of several linked genes.
The dothidiomycete Dothistroma septosporum, has several linked genes with strong similarity to genes in the sterigmatocystin and aflatoxin gene clusters of the distantly related Aspergillus genus (eurotiomycetes).
Indeed, if a single co-location of 2 QTLs could be due to chance alone, the observation of multiple co-locations could be considered as a good indication of a common genetic control of the different WPs, reflecting the effects of pleiotropic genes rather than the presence of several linked genes.
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The mvp mutation, encompassing the complete VRN1 gene and several closely linked genes, resulted in several differences in the metabolite composition compared to that of the wild type T. monococcum, which might be explained by the pleiotropic effect of the genes that are regulated by the MADS-box transcription factor VRN1.
In general, the presence of eQTL hotspots suggests either the presence of a master regulator gene which controls the expression of groups of genes together or the presence of several tightly linked genes within the hotspot, each of which regulates the expression of a subset of genes mapping to this locus [31], [33], [34].
The involvement of several Y linked genes and loci have been reported to be associated with the progression of PC [ 13, 14].
Despite involvement of several chromosomes in the etiology of PC, our focus remained on the Y chromosome of the two cell lines to assess several Y linked genes and DYZ1 regions.
Snell [ 13] continued the analysis of histocompatibility by breeding mouse strains that differed from one another at single histocompatibility loci, his so-called congenic strains (although we now know that each MHC is a composite of several closely linked genes).
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