A correlation between rht1 or sd1 haplotypes and any trait might be caused by the Green Revolution gene itself, but the large LD in tef indicates that many other linked genes would also be candidates for the causal agents.
Indeed, farmers and breeders selecting for domesticated alleles have probably also selected against many other tightly linked genes.
In contrast to many other, even closely linked genes, in which the majority of intron positions has been conserved for hundreds of millions of years, the intron distribution pattern of neuroserpin gene orthologs has experienced massive changes, perhaps dominated by intron gain.
Indeed, many short duplicated groups of linked genes were identified in the Takifugu rubripes and Tetraodon nigroviridis genomes [ 1, 7].
In many eukaryotes, physically linked gene pairs tend to be coexpressed.
There are abundant SNPs and SNIs among the sequences, with many linked to predicted gene sequences (Table 1).
Over the past 15 years, molecular genetic studies have linked gene mutations to many inherited arrhythmogenic disorders, in particular, "ion channelopathies", in which mutations in genes encode functional units of ion channels and/or their transporter-associated proteins in patients without primary cardiac structural abnormalities.
These studies identified many linked regions that may harbor the SLE susceptibility genes.
On the other hand, if we attempt to connect the weakly co-expressed genes into the network, the threshold may become so low that the genes in the strongly co-expressed pathway may have many links to genes in other pathways, making further analysis difficult.
Since the tagging of the Ur-4 bean rust (Uromyces appendiculatus) gene [ 11] many markers linked to genes and QTL controlling resistance to fungal, bacterial, and viral pathogens were developed by BSA approach using RAPD markers [ 5].
