Sentence examples for multiple related genes from inspiring English sources

This chapter reveals the advances in protein design termed "molecular breeding," allows protein engineers to homologously recombine multiple related genes by a process that closely mimics sexual recombination to generate functionally diverse libraries of chimeric proteins from which improved variants can be selected.

Furthermore, we could not determine whether changes in gene expression resulted from changes in the expression of a single gene or multiple related genes.

While sequence analysis was unable to identify potentially paralogous sequences, it is important to note that the bands observed in Fig. 3 could represent the expression patterns of multiple related genes.

Although variations and even outliers that can be introduced by technical issues or experimental variations that have nothing to do with biological relevance, the chance that multiple related genes in a pathway or biological process have such issues simultaneously should be rare.

One of the major goals of the SLEPR method is to consider sample-level specificity for gene-level variances, and place the identified genes in the context of a priori defined gene sets, annotated biological processes or pathways, functional categories (e.g., GO terms) and look for pathway-level consistency of enrichment effects from changes occurring at multiple related genes systematically.

However, it has proved difficult to infer pathways from microarray data by deriving modules of multiple related genes, rather than individual genes.

Homolog prediction is especially difficult when multiple related gene families are considered, as exemplified by the many diverse C2H2 ZNF gene families [ 2].

This defect is associated with decreased expression of multiple bone related genes [11].

Calvarial osteoblasts isolated from TIEG1 knockout (KO) mice display reduced expression levels of multiple bone related genes, including Runx2, and exhibit significant delays in their mineralization rates relative to wildtype controls.

Since TIEG1 and Runx2 are both transcription factors which are known to regulate multiple bone related genes, and since we have demonstrated that TIEG1 directly regulates Runx2 expression, we next examined whether TIEG1 could interact with the Runx2 protein and mediate its activity.

might be commonly utilized to coordinate the regulation of multiple closely related genes in keratinocytes.