Sentence examples for multiple functional states from inspiring English sources

The resulting framework, 'complex adaptive landscapes' (CAL), explicitly captures the reciprocal feedbacks and non-linear nature of interactions between components within and between system levels, and the consequent possibility of multiple functional states (alternate systems functioning).

Microglia, serving as resident immune cells of the retina, can have multiple functional states and carry out diverse functions [22].

Recent mammalian RyR1 cryoelectron microscopy (cryo-EM) structures of multiple functional states have clarified longstanding questions including the architecture of the transmembrane (TM) pore and cytoplasmic domains, the location and architecture of the channel gate, ligand-binding sites, and the gating mechanism.

Understanding of the architecture and gating of RyRs has advanced dramatically over the past two years, due to the publication of high resolution cryo-electron microscopy (cryoEM) reconstructions and associated atomic models of multiple functional states of the skeletal muscle receptor, RyR1.

High-resolution structure determination techniques such as crystallography, NMR, and cryo-electron microscopy are providing critical insights into ncRNA behavior but are challenged by the large sizes, conformational heterogeneity, and multiple functional states of most biological ncRNA domains (Weeks, 2010).

Many experimental techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, small-angle X-ray scattering (SAXS), and single-particle electron microscopy (EM) have indeed provided structural evidence at different resolutions to support the view of multiple functional states of biomolecules.

This dynamical network organizes into multiple robust functional states, including physiological and pathological ones.

Today nuclear pores are not anymore seen as static facilitators of nucleocytoplasmic transport but ensembles of multiple overlaying functional states that are involved in various cellular processes.

Integrated -omics approaches are quickly spreading across microbiology research labs, leading to (i) the possibility of detecting previously hidden features of microbial cells like multi-scale spatial organization and (ii) tracing molecular components across multiple cellular functional states.

Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins.

However, the availability of structures for multiple functional and/or conformational states of the same protein, or even within the same family, is limited.