Sentence examples for multiple chromosomal changes from inspiring English sources

In this study we describe a chromosomal cline in the Wood White butterfly, Leptidea sinapis (Insecta, Lepidoptera, Pieridae) that provides strong evidence for rapid and extensive within-species chromosome number evolution through accumulation of multiple chromosomal changes.

The cells surviving such overreplication constitute a heterogeneous population with multiple chromosomal changes, including partial or complete endoreduplication of chromosomes, as well as a variety of chromosomal rearrangements.

The discovered system represents the first clearly documented case of explosive chromosome number evolution through intraspecific and intrapopulation accumulation of multiple chromosomal changes.

However, frequently, this process cannot be proven in the individual patient who presents with multiple chromosomal changes at first diagnosis.

The discovered cline seems to represent a narrow time-window of the very first steps of species formation linked to multiple chromosomal changes that have occurred explosively.

Our laboratory has previously identified a rare subpopulation of variant human mammary epithelial cells (vHMEC) that have the capacity to propagate beyond an in vitro proliferation barrier and accumulate multiple chromosomal changes [ 1].

This study suggested that multiple chromosomal losses, as well as copy number changes at certain genomic regions, herald a shorter progression free survival and thus a worse prognosis [ 8].

Loss of multiple chromosomal regions is another genetic alteration frequently found in lung tumours.

The non-recurrent translocation group tends to show complex genomic changes including gains/amplifications and deletions in multiple chromosomal regions, [ 3, 6] or activating mutations (e.g. KIT and PDGFRA) in gastrointestinal stromal tumors (GIST).

Furthermore, the clinal geographical distribution of chromosomal races observed in some organisms [ 1, 2], apparently compatible with gradual within-species accumulation of chromosomal changes, may be better explained by the multiple speciation mechanism.

Regulation of phase variation can occur through multiple, different mechanisms, including homologous and site-specific recombination events that generate chromosomal changes that activate or inactivate expression of a gene [ 1], e.g., due to inversion of a promoter element.