Sentence examples for multiple chromosomal alterations from inspiring English sources
Accordingly, SIRT6−/− MEFs show impaired proliferation and enhanced sensitivity to DNA-damaging agents, resulting in multiple chromosomal alterations (fragmentation, detached chromosomes, gaps, and translocations) on the basis of a BER defect (Mostoslavsky et al. 2006).
Multiple chromosomal alterations have been reported in CaP [ 18- 20], including chromosome aneusomy, gain of the 8q24 (MYC) locus, and loss of 8p21-22 (LPL) [ 21], and 10q23 (PTEN), among others [ 22].
Early cytogenetic studies have identified multiple chromosomal alterations in Wilms tumors, raising the possibility that several steps in the differentiation pathway of blastemal cells could represent potential targets for tumorigenic events [ 1].
Notwithstanding several prominent mutations in the DNA repair genes, no increase in the number of mutations or CNVs was observed in the L-STS and H-STS, whereas the P-STS acquired multiple chromosomal alterations during in vitro cultivation not evident in the P-Tu.
Multiple recurring chromosomal alterations have been identified in acute lymphoblastic leukemia (ALL).
Regional epigenetic silencing and activation of multiple genes unrelated to chromosomal alterations may affect the pathological parameters of individual tumours.
Plasma-Seq identified again multiple prostate cancer-associated chromosomal alterations, such as 8p loss, gain of 8q regions, the 3-Mbp TMPRSS2-ERG deletion on chromosome 21, and AR amplification.
Loss of multiple chromosomal regions is another genetic alteration frequently found in lung tumours.
Expression analysis of 21 retinoblastomas by Kapatai et al. suggests the existence of two retinoblastoma sub-types: one expressing multiple retinal cell markers and aforementioned recurrent chromosomal alterations typical of retinoblastoma, and another with the characteristics of cone photoreceptors with high metabolic capacity and proliferation [61].
Malignant gastric tumors are known to carry multiple aberrations in their genome and such chromosomal alterations are crucial for the activation and inactivation of cancer-related genes [ 8- 17].
Recently, BoydLk et al. [ 32] pointed out that prostate cancer is a genetic disease characterized by multiple genomic alterations, including point mutations, microsatellite variations, and chromosomal alterations such as translocations, insertions, duplications, and deletions.
