Sentence examples for multiple chromosomal abnormalities from inspiring English sources

CDK1 downregulation led to the accumulation of cells with abnormal numbers of mitotic organelles, multiple chromosomal abnormalities and polyploidy.

MM is characterized by multiple chromosomal abnormalities of varying prognostic significance.

Chromosomal analysis revealed that culturing these normal-looking, tumorigenic mouse PA-MSC cause multiple chromosomal abnormalities.

Classical cytogenetic analysis of HNSCC tumours has revealed multiple chromosomal abnormalities and highly complex karyotypes.

Genome-wide studies have unraveled multiple chromosomal abnormalities with involvement of specific oncogenes and tumor suppressor genes [ 5, 6].

Cytogenetic studies have shown that multiple chromosomal abnormalities were frequently detected in individual cases, suggesting that genomic instability might play an important role in NPC pathogenesis [13], [14].

Apart from the 5q- syndrome [ 7, 16], patients with del 5q) MDS may present with one additional chromosomal abnormality, with multiple additional chromosomal abnormalities leading to a complex karyotype, or with an increase of bone marrow and/or peripheral blasts irrespective of chromosomal complexity.

E.g., multiple myeloma represents a plasma cell malignancy characterized by complex heterogeneous cytogenetic abnormalities and a significant amount of MSC derived from multiple myeloma carry chromosomal abnormalities and defects in gene and protein expression [ 128].

Multiple births, congenital malformations, chromosomal abnormalities, missing data on gestational age, and birth weight less than 500 g were excluded.

Twenty-three patients were excluded because of multiple gestations, structural or chromosomal abnormalities, or fetal death or for lack of available follow-up.

Our patients were diagnosed with multiple but not prognostic chromosomal abnormalities detected within the neoplastic cells.