Sentence examples for multiple chromosomal aberrations from inspiring English sources

Multiple chromosomal aberrations were identified, some of them located in regions with known tumor suppressor genes and oncogenes.

Differences were even more marked when cells with multiple chromosomal aberrations were scored, mainly after DEB exposure.

In no instance multiple chromosomal aberrations were observed in this control group, regardless that samples were exposed to DEB or not (Figure 8b).

Unsupervised hierarchical clustering analysis of the chromosomal profiles revealed two major clusters, characterised by either few or multiple chromosomal aberrations, respectively.

Using this technique it was revealed that both the metastatic M4A4, and the non-metastatic NM2C5 cell lines are hyperdiploid (modal number of 56 57) and contain multiple chromosomal aberrations.

5– 7 As GGP tumors show multiple chromosomal aberrations with partial gains and/or losses, unknown causes that induced genomic instability might have triggered NB genesis in the progenitor or stem cells of a sympathetic cell lineage.

The detailed procedures for allele frequency estimation and CPA adjustment are described in Appendix A. We develop multiple chromosomal aberration indices and a sliding-window approach in concert with a standard individual-level allele frequency plot to identify chromosomal aberrations such as aneuploidy, AI, LOH, long-contiguous-stretch-of-homozygosity (LCSH), and so on.

Musashi-1 facilitates malignant transformation through multiple acquired chromosomal aberrations (Siebzehnrubl et al, 2009) and is a CSC marker in tumours (Hemmings, 2010).

Sporadic hybrid oncocytic tumors have been shown to contain multiple numerical chromosomal aberrations including monosomies and polysomies of 1, 2, 6, 9, 10, 13, 17, 21, and 22 without any reported mutations in the VHL, c-kit, platelet-derived growth factor receptor alpha (PDGFRA), and FLCN genes [42], [45].

In recent years, multiple chromosomal and molecular aberrations have been discovered that contribute to the development of this disease.

Cancer cells contain multiple mutations and chromosomal aberrations, which can confer them growth advantage, principally owing to their accumulation.