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We infer from this study that silver nanoparticles could penetrate plant system and may impair stages of cell division causing chromatin bridge, stickiness, disturbed metaphase, multiple chromosomal breaks and cell disintegration.
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DNA structure has been described at multiple chromosomal translocation break points [36], particularly in cases where RAG recombinase is involved [37], [38].
These aberrations included multiple chromosomal fragments and subtelomeric chromatid breaks, resulting in telomeric associations.
To develop a measure of chromosomal instability, which takes into account the different sizes of the chromosomes, we assessed the density of chromosomal breaks for each chromosome, by normalizing the number of breaks per 100 Mb.
The heat map in Figure 5 illustrates the density of chromosomal breaks on individual chromosomes in all tumors.
Different types of chromosomal damage caused by asbestos fibers may be observed in asbestos-exposed cells, including chromosomal breaks and fragments (micronuclei), lagging chromosomes, exchange of chromosomal segments between two chromosomes and chromosomal missegregation.
To understand the role of DSBs in multiple cellular mechanisms, a robust method for genome-wide mapping of chromosomal breaks at one-nucleotide resolution is required.
We describe the number of chromosomal breaks as well as the patterns of breaks on individual chromosomes in each tumor.
Human TGCT are typically aneuploid with multiple chromosomal rearrangements (Oosterhuis et al., 1990).
Therefore, the objective of this study was to identify the structural factors involved in chromosomal breaks in ALL.
Some of the earliest hints of this came from disease-associated chromosomal breaks positioned well outside the relevant gene.
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