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Similar to BRCA1 −/− tumors, BRIT1 −/− tumors also display numerous chromosomal aberrations.
Resequencing 50 of the RHS deletion strains revealed numerous chromosomal aberrations, which mostly consisted of triploidies.
Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations.
18 Recent studies using comparative genomic hybridization and florescence in situ hybridization have shown that these techniques can be utilized to distinguish melanomas (which usually harbor numerous chromosomal aberrations) from nevi (which rarely harbor any aberrations).
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In addition to numerical chromosomal aberrations, GLI2ΔN-overexpressing keratinocytes presented with structural chromosomal abnormalities, such as translocations.
Notably, despite numerous and complex chromosomal aberrations in both tumors within these pairs, they clustered together.
Recent advances in molecular technologies have allowed the analysis of numerous gene and chromosomal aberrations within the entire genome.
Particles of nickel may cause some morphological transformations in numerous cellular systems and chromosomal aberrations [ 34].
These studies have revealed numerical and structural chromosomal aberrations.
The precise contribution of WHSC2/NELF-A gene deletions to this syndrome are not yet understood due to the variability of the associated chromosomal aberrations that remove numerous genes, and the lack of good animal models 45.
Completing this region also has significant implications for studying human disease given the numerous disorders associated with CNVs, mutations and chromosomal aberrations in the 1q21 region.
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