Sentence examples for multiple angiogenic pathways from inspiring English sources

However, the benefits of anti-angiogenic therapy can be limited by redundant mechanisms of angiogenesis control, a problem that may potentially be overcome by targeting multiple angiogenic pathways or the use of broad spectrum angiogenic inhibitors [6].

However, tumors may circumvent therapies aimed at a single signaling pathway via up-regulation of alternate pathways and therefore, targeting of multiple angiogenic pathways has been suggested [26], [27], [28].

Targeting multiple angiogenic pathways has been increasingly recognized as a viable strategy.

Thus, targeting multiple angiogenic pathways may not only improve antitumor activity but also reduce the risk of resistance.

Newer treatment strategies have focused on molecules that inhibit multiple angiogenic pathways involved in the development and progession of tumors.

However, already now, it seems very likely that efficient cancer therapy will be composed of combination of chemotherapy and anti-angiogenic strategies that target multiple angiogenic pathways.

Sunitinib, an oral tyrosine kinase inhibitor, targets multiple angiogenic signaling pathways, including VEGF and platelet-derived growth factor receptors, 4– 6 which may translate into increased antitumor activity when compared with single-target agents.

Hypoxia can promote vessel growth by upregulating multiple pro-angiogenic pathways [ 82].

The strong antivascular effect seen with nintedanib may result from its potential to simultaneously inhibit multiple angiogenic and mitogenic signalling pathways (mediated by VEGFR, PDGFR, FGFR, RET and Flt3 [ 25]), which may enable the drug to block compensatory angiogenic pathways that can be activated when anti-VEGF agents are used in isolation [ 3- 12].

Since we have found recently that SERPINA3K is an antagonist of the canonical Wnt pathway which regulates multiple angiogenic factors including VEGF and TNF-α [23].

Activation of Shh pathway upregulates the expression of multiple angiogenic cytokines, including VEGF, angiopoietins, SDF-1α and IGF-1 and development of capillary network [4], [17].