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In summary, our plasma angiome analysis in this phase II study identified multiple angiogenic markers with potential prognostic and/or predictive importance for CRC patients treated with bevacizumab in combination with capecitabine/oxaliplatin.
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We next tested an alternate multiple linear regression model including both angiogenic markers independently associated with the late-NVC pattern (circulating EPCs and VEGF serum levels) and SSc-related disease characteristics associated univariately with P ≤ 0.10 with the late-NVC pattern.
This result indicates that fullerene-containing materials serve as a potent antiangiogenesis inhibitor that can simultaneously target multiple angiogenic factors.
Gene expression of angiogenic markers VEGF and ANG-2 was higher on PCL/RGO_Cu compared to PCL.
We evaluated whether IVF pregnancies, when compared with those conceived spontaneously, would be associated with alterations in serum angiogenic markers.
The angiogenesis is a co-ordinated process that requires the participation of multiple angiogenic factors.
There were also relationships between the inflammatory markers and angiogenic markers.
Figure 2 shows serum levels of angiogenic markers before and after antihypertensive therapy.
However, the benefits of anti-angiogenic therapy can be limited by redundant mechanisms of angiogenesis control, a problem that may potentially be overcome by targeting multiple angiogenic pathways or the use of broad spectrum angiogenic inhibitors [6].
Interleukin-8 and interferon-γ associated with all three angiogenic markers with correlation coefficients of 0.50 to 0.73.
Furthermore, angiogenesis is a highly complex and tightly orchestrated multistep process involving extensive interplay between multiple angiogenic factors.
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