Sentence examples for several angiogenic pathways from inspiring English sources

Indeed, ECFC have been described to secrete several angiogenic pathways that modulate their ability to increase foot perfusion in this preclinical model [ 27].

This is likely to be due to redundancy in breast tumours with an individual tumour being able to utilise several angiogenic pathways at any one time [ 3] with changes in this profile during tumour progression coupled with the use of other mechanisms to establish a blood supply.

However, several important angiogenic pathways have been implicated in human tumour neovascularization.

Several IL-6-related angiogenic pathways have been reported, including IL-6/HIF signalling (Anglesio et al, 2011) in ovarian cancer and Stat3/VEGF signalling in breast cancer (Niu et al, 2002).

First, there is large-scale redundancy in blood supply to any tumour, allowing them to switch angiogenic pathways; this suggests that there is a need for several or multifunction agents.

Inhibition of angiogenic pathways has proven an effective strategy for the treatment of several common solid tumors however its role in the management of prostate cancer is yet to be defined.

Angiogenic pathways and mediators have been extensively studied as potential anti-cancer drugs for several decades.

The results might implicate that different angiogenic pathways exist in human breast cancer.

Our laboratory has identified IRESs in mRNAs of several angiogenic or lymphangiogenic growth factors.

TRC105 treatment by C2D1 was associated with decreases in several angiogenic factors, including Ang-2, PDGF isoforms, and VEGF isoforms, offering insight into the mechanisms underlying TRC105's anti-angiogenic, antitumor function.

However, the benefits of anti-angiogenic therapy can be limited by redundant mechanisms of angiogenesis control, a problem that may potentially be overcome by targeting multiple angiogenic pathways or the use of broad spectrum angiogenic inhibitors [6].