Sentence examples for multiple angiogenic agents from inspiring English sources

In vitro data suggests that thalidomide has anti- angiogenic activity, blocking the expression of multiple angiogenic agents (D'Amato et al, 1994).

Elucidation of the mechanisms of tumor angiogenesis has led to the development of multiple anti-angiogenic agents.

The main problem in the development of antiangiogenic agents is that multiple angiogenic molecules may be produced by tumors, and tumors at different stages of development may depend on different angiogenic factors for their blood supply.

Sunitinib, an oral tyrosine kinase inhibitor, targets multiple angiogenic signaling pathways, including VEGF and platelet-derived growth factor receptors, 4– 6 which may translate into increased antitumor activity when compared with single-target agents.

This result indicates that fullerene-containing materials serve as a potent antiangiogenesis inhibitor that can simultaneously target multiple angiogenic factors.

Therapeutic angiogenic agents are currently being examined for treatment of this disease.

The angiogenesis is a co-ordinated process that requires the participation of multiple angiogenic factors.

However, the benefits of anti-angiogenic therapy can be limited by redundant mechanisms of angiogenesis control, a problem that may potentially be overcome by targeting multiple angiogenic pathways or the use of broad spectrum angiogenic inhibitors [6].

The strong antivascular effect seen with nintedanib may result from its potential to simultaneously inhibit multiple angiogenic and mitogenic signalling pathways (mediated by VEGFR, PDGFR, FGFR, RET and Flt3 [ 25]), which may enable the drug to block compensatory angiogenic pathways that can be activated when anti-VEGF agents are used in isolation [ 3- 12].

Targeting multiple angiogenic pathways has been increasingly recognized as a viable strategy.

However, already now, it seems very likely that efficient cancer therapy will be composed of combination of chemotherapy and anti-angiogenic strategies that target multiple angiogenic pathways.