Sentence examples for mouse prostate development from inspiring English sources

Interestingly, Tmprss2 expression is induced late during mouse prostate development [59].

These results suggest that iASPP deficiency is unlikely to grossly affect mouse prostate development.

The mouse prostate development initiates from the urogenital sinus (UGS) [ 7].

Since p63 is required for mouse prostate development and its expression is lost in invasive PCa, we investigated whether iASPP plays a role in mouse prostate development through its ability to regulate p63.

Recent evidence has shown that in early, postnatal, mouse prostate development, epithelial homeostasis is maintained by basal multipotent stem cells that differentiate into basal, luminal, and neuroendocrine cells, as well as by unipotent basal and luminal progenitors [24].

These results suggest that iASPP deficiency facilitates p63-expressing progenitors to commit to the luminal cell linage by transitioning into intermediate cells, and that iASPP regulates mouse prostate development through its ability to inhibit cellular senescence and prostate epithelium differentiation.

Previous studies indicated that PTEN-deficient cancer cell lines mainly depend on p110β, and that p110β, but not p110α, controls mouse prostate cancer development driven by PTEN loss.

Considering that targeted expression of ETK in mouse prostate leads to the development of PIN [13], it is possible that ETK may also play a role in oncogenic transformation in bladder urothelial cells.

It has been shown that ETK overexpression can increase proliferation in mouse prostate epithelium and result in development of prostatic intraepithelial neoplasia (PIN) partly by increasing AKT and STAT3 activity [13].

These mice develop hyperplasia early during prostate development, rapidly progressing to invasive tumors, accompanied by metastases [15], [31].

Following castration, the transgenic adenocarcinoma of mouse prostate (TRAMP) model demonstrates rapid development of SV40-Tag-driven poorly differentiated tumors that express neuroendocrine cell markers.