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Specific components of the Wnt/β-catenin signalling pathway have been implicated in AR signalling in vitro [21] and with ADT in clinical PCa [22] as well as in murine prostate development and PCa progression [23].
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Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP).
Echoing these findings, deletion of Pten in the developing murine prostate leads to early onset and rapidly progressive neoplasia [4] [8].
The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer.
Murine prostate specific membrane antigen.
Murine prostate stem cell antigen.
Impaired FGF signaling promotes epithelial-mesenchymal transition and tumor progression in murine prostate cancer models [86].
In this study, we demonstrated that murine prostate epithelial stem cells are indeed susceptible to dissociation-induced apoptosis.
Dissociated murine prostate cells were suspended in DMEM/10% FBS and stained with antibodies for 15 min at 4°C.
Important aspects of early hyperplasia development and normal prostate development were sequentially addressed.
The expression of interesting proteins will be examined during fetal prostate development as well as in the adult prostate.
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