Sentence examples for mouse models demonstrating from inspiring English sources

We now have new data from newly developed mouse models demonstrating that MELK is not essential for normal physiological functions.

In particular, recent publications have addressed the relationship between the two events in mouse models demonstrating cooperation (Carver et al, 2009; King et al, 2009).

Furthermore, the specific deletion of two major tumor suppressor genes Ptc and Pten were identified in mouse models, demonstrating their important role in the suppression of MB formation.

Here, we report the data from preclinical experiments that we conducted by constructing genetically well-defined mouse models, demonstrating that Taspase1 ablation blocks MMTV-neu-driven breast cancer initiation in vivo.

However, this theory was recently challenged by contradictory data obtained in various mouse models demonstrating that although the overexpression of several antioxidant enzymes makes mice more resistant to oxidative challenge, it fails to increase their lifespan.

Whilst the data from mouse models demonstrating a role for the immune system and T-bet in the regulation of insulin sensitivity during obesity is compelling, much less convincing data exists from human patients.

Studies using genetically engineered mouse models demonstrated a central role of JAK2 V617F in the pathogenesis of MPNs.

Evidence from mouse models demonstrates that genetic or pharmacological inhibition of RORγ activity can block the production of pathogenic cytokines, including IL-17, and convey therapeutic benefit.

Genetically engineered mouse models demonstrated that HAI-1 is critical for epidermal function, possibly through direct and indirect regulation of cell surface proteases, such as matriptase and prostasin.

Our engineered mouse models demonstrate the oncogenic potential of pseudogenes and indicate that ceRNA-mediated microRNA sequestration may contribute to the development of cancer.

First, the cross of these mouse models demonstrated that genetic deletion of NE results in a substantial reduction of neutrophils in BAL from βENaC-Tg mice confirming an important role of this protease in neutrophilic airway inflammation [15].